15 results
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... phase symptoms Signs ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis ... #signs #symptoms
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
Lipid mediators (e.g ... Other mediators (e.g ... of inflammatory cells ... #Anaphylaxis #pathophysiology ... #immunology
A Lewis Lead (also called the S5 lead) is a modified ECG lead used to detect
is a modified ECG ... clinically, based on signs ... standard 12 lead ECG ... Lead I on the ECG ... #Cardiology #EKG
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
Signs of immunodeficiency ... humoral immunity Signs ... bacterial infections (e.g ... Agammaglobulinemia #XLinked #pathophysiology ... #immunology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
excess secretion of hCG ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... tissue expansion (e.g ... #FeedbackLoop #endocrinology ... #pathophysiology
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Ag-presenting cells ... or plasma cells ... storage sites (e.g ... Humoral #Immunity #pathophysiology ... #immunology
Bone resorption and the relationship between osteoblasts and osteoclasts.  
RANK is expressed on the osteoclasts,
expressed on marrow cells ... linking proteins (e.g ... Several acids (e.g ... #Pathophysiology ... #Endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
diffusion of K+ out of cells ... Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... Lysis of tumor cells ... unless worrisome EKG