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diagnosis rheumatology lupus management systemic differential vasculitis workup activation ana antibodies antinuclear arthritis cerebritis chronic classification cll cns cryoglobulinemia cryoglobulins
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
(SLE) Clinical ... Demyelinating Syndrome ... Disease, PRES Pathophysiology ... #SLE #CNS #neurology ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... Malignancy (e.g. hematologic ... Clinical Features ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Systemic Lupus (SLE ... Demyelinating syndromes ... ) Blood (75%): Anemia ... #systemic #erythematosus
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence microscopy ... likely it will be clinically ... Syndrome (SS), ... Arthritis, Sjögren Syndrome ... ANA #patterns #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... diseases: - 10% SLE ... vasculitis - GPA, EGPA, microscopic ... systemic lupus erythematosus ... (SLE), rheumatoid
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... Clinical Presentation ... Fever is the main clinical ... [SLE], AOSD) • ... with leukopenia, anemia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Orange or Hep C Clinical ... • Neutropenia, anemia ... • Richter’s Syndrome ... workup #oncology #hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... polarized light microscopy ... Systemic lupus erythematosus ... the presence of anemia ... ANA and RF (if clinical
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... Multinucleated giant cells ... ischemia • Skin: Erythematous ... (PR3-ANCA)): Microscopic ... vasculitis • Cogan syndrome
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
overgrowth of cells ... systemic lupus erythematosus ... (SLE), Sjögren’ ... cell lymphoma Pathophysiology ... diagnosis #management #rheumatology
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