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diagnosis menstrualcycle ovariancycle agammaglobulinemia cellular comparison disruptors drainage feedbackloop flow follicularphase fracture gh growthhormone healing humoral immuneresponses msk orthopedics osteoclasts
Bone resorption and the relationship between osteoblasts and osteoclasts. RANK is expressed on the osteoclasts,
Bone resorption ... expressed on marrow cells ... the surface of bone ... #Pathophysiology ... #Endocrinology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... IGFIR activates osteoblasts ... #FeedbackLoop #endocrinology ... #pathophysiology
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
osteoprogenitor cells ... forms bony callus ... coupled bone remodeling ... from GI tract, bone ... #msk #Staging #pathophysiology
Cellular and humoral immune responses of the adaptive immune system. Activated T cells accomplish cellular immune
Activated T cells ... involves two paths, one ... response) and one ... ImmuneResponses #immunology ... #pathophysiology
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
maturation of B cells ... from precursor cells ... in blood and bone ... Agammaglobulinemia #XLinked #pathophysiology ... #immunology
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Sporadic mutation -> One ... gene mutated in one ... mutated in all cells ... Retinoblastoma #pathophysiology ... #ophthalmology
Aqueous Humor Production and Drainage • Provides nutrition, removes wastes, and transports neurotransmitters to the avascular
Circulates inflammatory cells ... circulation #AqueousHumor ... Drainage #flow #Pathophysiology ... #ophthalmology
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained Early Follicular Phase (Days 0-5) • Granulosa cells
• Granulosa cells ... follicle (the one ... growth (this is one ... #OvarianCycle #pathophysiology ... FollicularPhase #endocrinology
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles Note: Some charts show different relative levels of
• One follicle ... and granulosa cells ... granulosa and theca cells ... #OvarianCycle #pathophysiology ... #comparison #endocrinology
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