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diagnosis signs gh growthhormone syndrome centralretinalartery crao cushings diabetes diabeticketoacidosis dka excess feedbackloop hashimotos hashitoxicosis hypercortisolism hypothyroid management myopathy occlusion
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... share the same pathophysiology ... diagnosis #signs #symptoms ... #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... - Giantism or acromegaly ... thickness) - metabolic ... #FeedbackLoop #endocrinology ... #pathophysiology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... Hypogonad (50%) • Metabolic ... malignancy Pathophysiology ... Diagnosis #Management #Endocrinology ... #Treatment #Pathophysiology
Hypothyroid Myopathy Very common (up to 80% ) in patients with hypothyroidism Pathophysiology: • T4 deficiency leads to
hypothyroidism Pathophysiology ... mitochondrial oxidative metabolism ... Hypothyroid #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
Refeeding Syndrome: Pathogenesis and clinical findings Patients at Risk of Refeeding Syndrome: - Little or no nutritional
• Incr Glucose Metabolism ... Syndrome - Metabolic ... PO4 and Mg into cells ... Syndrome #diagnosis #pathophysiology ... #symptoms #signs
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
mutated in all cells ... Retinoblastoma Signs / Symptoms ... Retinoblastoma #pathophysiology ... #ophthalmology ... diagnosis #signs #symptoms
Hashitoxicosis ‘Leakage’ symptoms of active Hashimoto’s disease - Hashitoxicosis (Htx) can occur during the initial hyperthyroid stage in
Hashitoxicosis ‘Leakage’ symptoms ... lymphocytes and plasma cells ... ‘Leakage’ symptoms ... Hashitoxicosis #Hashimotos #Endocrinology ... #Diagnosis #Pathophysiology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
diffusion of K+ out of cells ... Due to neuronal metabolism ... Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
Retina • Ganglion cells ... Occlusion #CRAO #pathophysiology ... #ophthalmology ... diagnosis #signs #symptoms
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features 1) Skin • Thin, easily bruisable skin with
Endocrine and metabolic ... hypernatremia, metabolic ... abdominal CT, pelvis ... Diagnosis #signs #symptoms ... #endocrinology
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