31 results
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
Allergic reaction ... Particular CD4+ Th cells ... harmful -> Th Cells ... macrophages, mast cells ... #Immunology #pathophysiology
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... plasma cells that ... complexes bind to mast cells ... • Inflammatory cells ... #Immunology #pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Innate Immune Cells - Pathophysiology
The innate immune system consists of granulocytes, mast cells, natural killer cells,
Innate Immune Cells ... - Pathophysiology ... natural killer cells ... #Pathophysiology ... #immunology
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Immunosuppressant #Drugs #Pharmacology ... #Pathophysiology ... #immunology
Type II Hypersensitivity: Pathogenesis and clinical findings
Definition: When antigens bind to the body's cell surfaces, forming
surfaces of body cells ... body cell -> B-Cells ... foreign -> B-cells ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Allergic Rhinitis: Pathogenesis and clinical findings

1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Allergic Rhinitis ... Allergy Sensitization ... -> Helper T cells ... Tissue edema #Allergic ... Rhinitis #Rhinorrhea #pathophysiology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Soluble antigen - Allergen-specific ... When the specific allergen ... natural killer cells ... Classification #Pathophysiology ... #Allergy #Diagnosis
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
exposure to a likely allergen ... exposure to known allergen ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
How dendritic cells (DCs) orchestrate adaptive immunity
1- Sensing of microbial and damage signals by DCs
2- Phenotypic
How dendritic cells ... adaptive #immunity #immunology ... #pathophysiology