8 results
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Immune Reactions ... Basiliximab - IL-2 receptor ... Immunosuppressant #Drugs #Pharmacology ... #Pathophysiology ... #immunology
Type II Hypersensitivity: Pathogenesis and clinical findings
Definition: When antigens bind to the body's cell surfaces, forming
Antigen binds receptor ... foreign -> B-cells ... the cell surface receptor ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Anaphylaxis: Treatments (Acute)
Additional Info:
 • IV steroids may be considered for prevention of late phase reactions.
of late phase reactions ... provided, as well as allergy ... • H2 receptor ... Treatments #Management #pathophysiology ... #immunology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
via their Fc receptor ... When the specific allergen ... Classification #Pathophysiology ... #Allergy #Diagnosis ... #Reactions #Table
Antiarrhythmics - Vaughan Williams Classification
Class I (Ia, Ib, Ic) - Na+ Channel Blockade
 • Slows depolarization
depolarization in fast AP cells ... Class II - Beta Receptor ... Blockade • Prolongs action ... Classification #Classes #cardiology ... #pharmacology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
beta adrenergic receptors ... ++ influx into cells ... Vaughan #Williams #Pharmacology ... Classification #Classes #pathophysiology ... #cardiology
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... beta adrenergic receptors ... inotropy) ACCP Cardiology ... Classification #Classes #pathophysiology ... #phases #cardiology
Adrenoceptor Actions
α1
 • Vascular smooth muscle - Contraction
 • Genitourinary smooth muscle - Contraction
 • Intestinal
Adrenoceptor Actions ... • Pancreatic ß-cells ... Adrenoceptor #adrenergic #receptors ... #actions #pharmacology ... #pathophysiology