17 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... younger pts) Differential ... sensitize red blood cells ... disease #hemolytic #anemia
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... Pelger-Huet, Macrocytic anemia ... or λ), Smudge Cells ... Amy Chung, MD, MSc ... hematology #Markers #Differential
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold agglutinins ... Consider RBC membrane disorder ... ARUPLabs #Hemolytic #Anemia
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... • Pernicious Anemia ... • Small Bowel Disorder ... • Pernicious Anemia ... #Macrocytic #Anemia
Causes of Dizziness / Lightheadedness - Differential Diagnosis Algorithm
Lightheaded, unsteady, disoriented - Non-vertigo
Organic Disease
 • Presyncope/Vasodepressor
Lightheadedness - Differential ... Hyperventilation • Anemia ... Anxiety • Panic Disorder ... Lightheadedness #Neurology ... #Differential #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... . primary cold agglutin ... lymphoproliferative disorders ... Extravascular #Causes #differential ... diagnosis #hematology #anemia
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Generalized Weakness - Differential ... ILD, OSA, pHTN, Anemia ... Polyneuropathy, ALS), NMJ disorder ... Generalized #Weakness #Differential ... Diagnosis #causes #neurology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Thrombocytopenia and Platelet Disorders ... - Differential ... (CVID, WAS), (neurologic ... changes), high MCV anemia ... #Differential #
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Causes of Fatigue - Differential ... Hematologic • Anemia ... Pulmonary Disease Neurologic ... • Somatization Disorder ... Chronic #Fatigue #Differential
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
blood cell count (anemia ... • Aplastic Anemia ... Megaloblastic Anemia ... Myelophthisic Anemia ... dyserythropoietic anemia