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diagnosis amyloid amyloidosis autoinflammatory cytokine differential e1 hematology hemeonc hemophagocytic hhv8 hlh immune iris kaposi kics kshv lymphohistiocytosis reconstitution rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... and/or 2) Inflammatory ... hematopoietic stem cells ... blood myeloid cells ... NEJM Review: https
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Clinical suspicion ... Amyloidosis Clinical ... : • Nephrotic syndrome ... Increased plasma cells ... polarized light microscopy
KSHV Inflammatory Cytokine Syndrome (KICS) Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
KSHV Inflammatory ... Cytokine Syndrome ... peripheral mononuclear cells ... 100 copies/ cells ... Kaposi #diagnosis #management
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Syndrome - Overview ... increase in CD4+ cells ... noncompliance • Clinical ... initiation Clinical ... #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... Clinical Presentation ... function of NK cells ... and CD8+ T cells ... Overproduction of pro-inflammatory
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