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diagnosis differential leukemia management algorithm classification rheumatology causes comparison dermatology diffuse disorders hemeonc lad lymphadenopathy lymphoma lymphomas lymphoproliferative mds myelodysplasia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... smear: Smudge cells ... or basket cells ... #Chronic #Lymphocytic ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
lymphadenopathy • Blast cells ... : Granulocytic cells ... (Chronic Lymphocytic ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... , smudge cells are ... uw_IMresidency #CLL ... #Chronic #Lymphocytic
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Age > 50 • Chronic ... Reed-Sternberg Cells ... Biopsy • Hodgkin's ... Algorithm #Causes #Hematology ... #Oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
cells. ... Workup: • Full ... Lymphoma Treatment ... classification #hematology ... #oncology #management
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Reed-Sternberg (RS) Cells ... - 5% RS cells absent ... (LP) tumour B cells ... common - T Cell ... ~10% - B-Cell
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Marrow Failure • Chronic ... Workup: • Complete ... Syndromes #diagnosis #hematology ... #oncology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
aggregate foci (>50 cells ... , B cells, and plasma ... cells around salivary ... lymphoma • B cell ... lymphoma • Large B cell
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
CRP GCA (Giant Cell ... Multinucleated giant cells ... elevated protein, lymphocytic ... Eosinophilia, asthma, chronic ... Differential #Diagnosis #Rheumatology
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
biopsy demonstrates lymphocytes ... , plasma cells, ... the mainstay of treatment ... frequent in men Chronic ... hematopoietic stem cell
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