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diagnosis hematology antibiotics apml differentiation fever hemeonc hemophagocytic hlh infant leukostasis lp lymphohistiocytosis lysis oncology peds risk stepbystep stratification tls
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... serious bacterial infections ... #Diagnosis #Management ... #Pediatrics #Peds ... #Febrile #Infant
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
ischemia, bowel infarction ... organ damage • Treatment ... : - If febrile ... Lysis of tumor cells ... TLS #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Rare: DAH, acute febrile ... Differential Diagnosis: Infection ... APML #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... consideration in febrile ... hyperinflammatory syndrome ... Triggers: ▪ Infections ... underlying trigger: Infections
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