26 results
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Limb- proximal weakness ... test - Cogan sign ... - Peek sign ... immunologic assay - MuSK ... diagnosis #management #neurology
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Generalized Weakness ... Resp/Heme: CHF, valves ... stroke, tumor), LMN ... NMJ disorder (Myasthenia ... Diagnosis #causes #neurology
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
age 50 years in men ... or respiratory weakness ... mild to moderate weakness ... or generalized weakness ... diagnosis #management #neurology
Radiculopathy: Signs and Symptoms
 • Back/Neck Pain
 • Decr Range of motion
 • Abnormal posturing
 •
Radiculopathy: Signs ... over time) • Weakness ... : • Straight leg ... Radiculopathy #MSK ... #diagnosis #signs
Incomplete spinal cord syndromes (ISCS)
 • Central - Small Lesion - Suspended sensory deficit, classic cape
positive Romberg sign ... , variable weakness ... - Ipsilateral weakness ... weakness (purely ... syndromes #diagnosis #neurology
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Demyelinating Disease (MS ... Eaton Syndrome, Myasthenia ... Neuromuscular #Weakness ... differential #diagnosis #neurology
Ocular Myasthenia Gravis on Physical Exam

A 41yo female was referred by her neurologist for double vision.
Ocular Myasthenia ... non-localized EOM weakness ... such as cogan sign ... tumor, and always ask ... ophthalmology #neurology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Postsynaptic: Myasthenia ... - Lack of UMN/LMN ... signs - Lack ... aminotransferases • Serology ... Differential #Diagnosis #neurology
Clinical Features and Vascular Territories of Stroke
Anterior circulation—anterior cerebral artery (ACA) - Contralateral leg weakness
Anterior circulation—middle
Contralateral leg ... weakness Anterior ... weakness, sensory ... without cortical signs ... CVA #Diagnosis #Neurology
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
saddle anesthesia. leg ... weakness and ... pathophysiology #signs ... #symptoms #msk ... #orthopedics #neurology