10 results
Leser–Trélat Sign on Physical Exam

Acute onset of multiple seborrheic keratoses, often a paraneoplastic sign of malignancy.

#Leser
Leser–Trélat Sign ... #Leser #Trélat # ... Trelat #LeserTrelat ... #video #skin #dermatology
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
anticoagulation #doac #noac #pharmacology ... #hematology #reversal ... #toxicology
Back to the "10 Need to Know" series - Drug Therapeutic Target Levels. 

For lithium, target
mortality at a higher level ... Therapeutic #Ranges #Toxicology ... #Pharmacology #
Therapeutic Drug Level Monitoring 
Carbamazepine - Sample immediately before next dose (trough) 
Clozapine - Sample immediately
Therapeutic Drug Level ... Sample trough level ... Therapeutic #Ranges #Toxicology ... #Pharmacology #
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... metabolized in the liver ... #Clozapine #Toxicology ... Toxicity #Diagnosis #Pharmacology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
Dermatomyositis • Fever ... disease and ILD • Liver ... Liver biopsies show ... Abs, and to a lesser ... #rheumatology #dermatology
Atopic Dermatitis - Topical Treatment Options 
First Line: Topical Corticosteroids 
  - High Potency: Betamethasone
After non-pharmacologic ... has a different level ... #Medications #Pharmacology ... #Dermatology #Management
Digoxin Pharmacology and Monitoring

 • Digoxin’s half-life is 30-45 hours in healthy adults
 • When monitoring
Digoxin Pharmacology ... elevated digoxin level ... - Any level ... Kat_Watson #Digoxin #Pharmacology ... #Monitoring #toxicology
Phases of Colchicine Toxicity
 - Early Phase (0-24h) 
 - Multi-organ failure Phase (1-7 days)
Renal failure, Liver ... Colchicine #Toxicity #Toxicology ... #Phases #Pharmacology
Methotrexate Toxicology 

Intravenous leucovorin (folinic acid) treatment serves as a cofactor necessary for synthesis of thymidylate
Methotrexate Toxicology ... the serum MTX level ... even if the MTX level ... Leucovorin #Antidote #Toxicology ... Toxicity #Management #Pharmacology