16 results
Leser–Trélat Sign on Physical Exam

Acute onset of multiple seborrheic keratoses, often a paraneoplastic sign of malignancy.

#Leser
Leser–Trélat Sign ... #Leser #Trélat # ... Trelat #LeserTrelat
Back to the "10 Need to Know" series - Drug Therapeutic Target Levels. 

For lithium, target
Therapeutic range ... mortality at a higher level ... #Therapeutic #Ranges ... #Toxicology #Pharmacology
Therapeutic Drug Level Monitoring 
Carbamazepine - Sample immediately before next dose (trough) 
Clozapine - Sample immediately
Therapeutic Drug Level ... Sample trough level ... #Therapeutic #Ranges ... #Toxicology #Pharmacology
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... metabolized in the liver ... #Clozapine #Toxicology ... Toxicity #Diagnosis #Pharmacology
ProBNP (pro B-type natriuretic peptide) is secreted by cardiomyocytes in response to stretch and is quickly
on a biological level ... half-lives of BNP range ... and to a much lesser ... organs with high rates ... (e.g. muscle, liver
Antifungal Organ System Tissue Penetration

Concentrations in tissues and body fluids for each systemic antifungal agent relative
column give the range ... Red, from below level ... secretions; x3, below level ... Concentrations #Pharmacology
Characteristics of Commonly Used Phosphate Binders 
Aluminum 
 - Potent and effective 
 - Useful for
absorption - Lowers level ... effective over wide pH range ... effective over wide pH range ... Table #Comparison #Pharmacology
Lelli's Test (Lever Sign) for ACL Injury

A fist is placed under the proximal 3rd of the
Lelli's Test (Lever ... Via Angel Nuñez ... #Lellis #Test #Lever
Digoxin Pharmacology and Monitoring

 • Digoxin’s half-life is 30-45 hours in healthy adults
 • When monitoring
Digoxin Pharmacology ... despite reference ranges ... - Any level ... Kat_Watson #Digoxin #Pharmacology ... #Monitoring #toxicology
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
desired serum K range ... Dosing: 15 g (4 level ... #medications #pharmacology