13 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
recessive salt-losing ... thiazide-sensitive sodium-chloride ... H+ secretion → Hypokalemia ... Metabolic alkalosis ... Pathophysiology #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Algorithm Before ... A urine K/Cr ratio ... • Diarrhea A urine ... Bartter syndrome, Gitelman ... differential #potassium #nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Diagnosis Algorithm ... Bartter syndrome, Gitelman ... #causes #potassium ... #low #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Differential Diagnosis Algorithm ... (late) • High Urine ... Bartter Syndrome, Gitelman ... #Nephrology #Causes
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Urinary Chloride Algorithm ... Bartter syndrome, Gitelman ... the indicated causes ... sodium is typically ... #Algorithm #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
hypokalemic salt-losing ... thiazide-sensitive sodium ... thiazide-sensitive sodium ... Hypocalciuria (spot urine ... Syndrome #diagnosis #nephrology
Hypokalemia Differential Algorithm
Acidosis
 - RTA
 - Diarrhea
pH Normal 
 1. Decreased Mg 
 2. Intracellular Shift
Hypokalemia Differential ... Algorithm Acidosis ... Metabolic alkalosis ... #Diagnosis #Causes ... #Workup #Nephrology
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Hypokalemia - Hypomagnesemia ... - Metabolic Alkalosis ... Elevated Renin Urine ... #nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Causes of Hyponatremia ... Differential Diagnosis Algorithm ... deficiency, Salt-losing ... tubal acidosis and metabolic ... #Causes #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Differential Diagnosis Algorithm ... (late) • High Urine ... Bartter Syndrome, Gitelman ... #Nephrology #Causes