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diagnosis differential pharmacology potassium binders binding cardiology comparison digoxin gitelman hypertension hyponatremia hypotonic management medications physiologic screening secondary syndrome treatment
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
as necessary at 1- ... • Mechanism: Sodium-K ... level teaspoons) 1- ... ); nausea, vomiting ... #pharmacology #table
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
prevalence of 1- ... thiazide-sensitive sodium-chloride ... nephron → - ↑ K+ ... H+ secretion → Hypokalemia ... #nephrology #diagnosis
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Pharmacology and Pathophysiology ... 1) Na/K ATPase ... Pump - Digoxin works ... intracellular calcium causes ... - Hyperkalemia (
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... Urine Na+K / serum ... Na >1 is predictive ... : Hypovolemia, Hypervolemia ... #sodium #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
reabsorption) Workup ... only if no clear cause ... Elimination (see Table ... 5-10U reg IV + 1- ... Treatment #potassium #nephrology
Causes of Secondary Hypertension - Differential Diagnosis and Screening Testing Common causes: • Renal parenchymal disease
(correction of hypokalemia ... Oral sodium loading ... syndrome - Overnight 1- ... #Screening #Workup ... #table
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