22 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... Dx: • ↑ Leukocyte ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Pathophysiology ... #APML #diagnosis ... #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... only curative treatment ... Myelodysplastic #Syndrome ... Diagnosis #Management #treatment ... #hematology #oncology
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
CPPD vs Gout ... disease states Pathophysiology ... • Metabolic syndrome ... Intracellular (leukocyte ... #Comparison #rheumatology
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... (both ALL and AML ... malignancies Treatments ... #Tumor #Lysis #Syndrome ... #TLS #oncology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... organ damage • Treatment ... : • Pathophysiology ... Low calcium • Treatment ... diagnosis #management #hematology
BRASH Syndrome

B - Bradycardia
R - Renal failure
A - AV nodal blockade
S - Shock
H - Hyperkalemia

Typical ECG
BRASH Syndrome ... waves (Bradycardia out ... hyperkalemia) BRASH Treatment ... • Aggressive treatment ... diagnosis #management #pathophysiology
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
sex • Metabolic syndrome ... Intracellular (leukocyte ... cortical bone Treatment ... treatment; consider ... #rheumatology
Management of Abdominal Distension and Bloating - Treatment Algorithm

Definitions
Pathophysiology
Organic/Pathologic Etiologies:
 • Small Intestinal Bowel Overgrowth (SIBO)
and Bloating - Treatment ... Definitions Pathophysiology ... Disorders of Gut-Brain ... Irritable Bowel Syndrome ... Diagnosis #Algorithm #Treatment
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
anemia DDX: Rule Out ... factor (GCSF) treatments ... marrow studies Treatment ... #diagnosis #hematology ... #oncology