24 results
hematopoiesis - leukocyte maturation tree

- Amy Chung, MD, MSc @AmyChung 

#hematopoiesis #leukocytes #maturation #tree #pathophysiology #Hematology
hematopoiesis - leukocyte ... Amy Chung, MD, MSc ... maturation #tree #pathophysiology ... #Hematology #Progenitor ... #Cells #WBC #pathology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Diagnosis Framework ... , erythema and WBC ... effusion with few WBCs ... morning • Effusion leukocyte ... #Diagnosis #MSK
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Approach to Joint Pain ... - Diagnostic Framework ... #Joint #Pain #MSK ... #rheumatology # ... #differential #diagnosis
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Approach to Joint Pain ... History: Is the pain ... #MSK #rheumatology ... #differential #diagnosis ... #arthritis
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... onset of swelling, pain ... Synovial Fluid: • WBCs ... Fluid Testing: • WBCs ... Intracellular (leukocyte
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
peripheral blood leukocytes ... Differential Diagnosis ... #differential #diagnosis ... #CBC #hematology ... #pathophysiology
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
- Differential Diagnosis ... Fever/Chills/Joint pain ... Effusions: - Hematologic ... #differential #diagnosis ... #msk #physicalexam
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... • Placenta • Leukocytes ... Bone symptoms - Pain ... biliary Cholangitis (PBC ... #Algorithm #hepatology
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
weight-bear • Arthritic ... Leg • Shooting pains ... FemoralHead #Fractures #msk ... #diagnosis #pathophysiology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... if high risk if WBC ... effusions, weight gain ... QD until normal WBC ... #management #hematology