15 results
Antiplatelet Drugs and their Actions

- Amy Chung, MD, MSc
@AmyChung

#Antiplatelet #Medications #Pharmacology #Pathophysiology #Drugs #Agents #COX #GIIbIIIa
Drugs and their Actions ... #Medications #Pharmacology ... #Pathophysiology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
constipation • Allergic reaction ... mediated cytotoxic reaction ... Stevens-Johnson Syndrome ... #SideEffects #Pathophysiology ... #Psychiatry #Pharmacology
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Immune Reactions ... Immunosuppressant #Drugs #Pharmacology ... #Pathophysiology
Renal Effect of NSAIDs Inhibition of Prostaglandin Synthesis

 - Renal disease, Cardiovascular disease -> Decreased renal
synthesis, leaving actions ... Prostaglandins #Pharmacology ... #Pathophysiology
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
• Serotonin Syndrome ... SSRI Withdrawal Syndrome ... Serotonin #Inhibitors #Pathophysiology ... #Pharmacology #
Anisocoria Evaluation Flow Chart - Differential Diagnosis
1. Check pupillary reaction to light 
2. Measure pupil size.
Check pupillary reaction ... - Horner's Syndrome ... CN III Palsy - Pharmacologic
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Vomiting Serotonin Syndrome ... SerotoninNorepinephrine #Inhibitors #Pathophysiology ... #Pharmacology #
Peripheral Edema - Differential Diagnosis Framework for Lower Extremity Edema

Edema occurs when any of the following
• May-Thurner Syndrome ... regional pain syndrome ... • SVC syndrome ... ) • Allergic reaction ... #PhysicalExam #Pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
Allergic reaction ... Stevens-Johnson Syndrome ... Allergy #Immunology #pathophysiology
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19

IL-6 activates T cells and macrophages, among other cell types (see
Cytokine Activation Syndrome ... 22% - Infusion reaction ... Siltuximab #COVID19 #Pharmacology