251 results
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
A reaction to phagocytosed ... sex • Metabolic syndrome ... Intracellular (leukocyte ... • Acute gout treatment ... severe allergic reactions
Symptoms Distinguishing Groups of Cutaneous Drug Reactions
IgE-mediated reactions:
 • Onset minutes to hours into treatment course
Cutaneous Drug Reactions ... IgE-mediated reactions ... to hours into treatment ... Onset days into treatment ... to weeks into treatment
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Penicillin-induced drug reaction ... Stevens-Johnson Syndrome ... Dermatitis (ie. reaction ... Allergy #Allergic #Reactions
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
• Blasts > 10% leukocytes ... Splenomegaly • ↑ Leukocyte ... develop leukostasis syndrome ... AML Dx: • ↑ Leukocyte ... • Tumor lysis syndrome
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... , POEMS • Reaction ... Exercise, Allergic reactions
Evaluation of Leukocytosis:
The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages.
Include
Leukocytosis: The term 'leukocyte ... Leukemoid reaction ... Leukemoid Reaction ... in a leukemoid reaction ... precursor cells to leukocytes
Hyperthermia Syndromes Comparison
Serotonin Syndrome - NMS - Malignant Hyperthermia - Malignant Catatonia
Cause - Onset - Vitals
Hyperthermia Syndromes ... Comparison Serotonin Syndrome ... Mental Status - Treatment ... #Hyperthermia #Syndromes
Summary of Infections in which Steroids play a role in treatment
 • TB meningitis
 • TB
play a role in treatment ... reconstitution inflammatory syndrome ... • Ramsay Hunt syndrome ... • Severe lepra reaction ... infections #management #treatment
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
anemias, hemolytic reactions ... Crigler-Najjar syndrome ... , drug reactions ... Dubin-Johnson syndrome ... , Rotor syndrome
Drug Reaction with Eosinophilia and Systemic Signs (DRESS Syndrome): Formerly known as drug hypersensitivity reaction, DRESS
represents
Drug Reaction with ... Systemic Signs (DRESS Syndrome ... hypersensitivity reaction ... with allergic reaction ... SkinRash #DRESS #Syndrome