13 results
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Associated Rheumatic Diseases ... ), Sjogren's Syndrome ... Kumfer @AnnKumfer #Antinuclear ... #rheumatology #
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... ), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... Kumfer @AnnKumfer #Antinuclear ... #rheumatology #
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Erythematosus - Summary Antinuclear ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology ... #management
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
• Is there a pattern ... morning • Effusion leukocyte ... an asymmetric pattern ... arthritis • SLE ... Symmetrical: • RA • SLE
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... bone pain, fever, joint ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... , PRES Pathophysiology ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
vesicular eruption - Joints ... - (C-ANCA) pattern ... - (P-ANCA) pattern ... vasculitis, and SLE ... differential #diagnosis #rheumatology
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
• Underlying disease ... states Pathophysiology ... • Metabolic syndrome ... Intracellular (leukocyte ... Gout #Comparison #rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA, SLE ... ab • RF • Antinuclear ... #Rheumatology # ... Diagnosis #Management
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
erythematosus (SLE ... , Lyme disease, ... cell lymphoma Pathophysiology ... TAFRO #diagnosis #management ... #rheumatology #