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oncology anemia blood product reactions cll coagulation dic disseminated hemolysis hemolytic leukemia lymphocytic mds myelodysplasia myelodysplastic syndromes transfusion transfusions
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... hemoglobinuria (PNH) Extravascular ... Hemolysis #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Diagnosis Algorithm ... Megakaryopoiesis • Aplastic ... Diagnosis #Algorithm ... #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
infections/fevers • Thrombocytopenia ... and petechiae Causes ... anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... #Disseminated #Intravascular ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Neutropenia, anemia, thrombocytopenia ... Pure red cell aplasia ... microglobulin Treatment ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Anemia • Aplastic ... Marrow Failure • Chronic ... blood count with differential ... #diagnosis #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
severe thrombocytopenia ... progresses to pancytopenia ... due to marrow aplasia ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
proteins on plts, leukocytes ... severe thrombocytopenia ... due to marrow aplasia ... #Transfusion #diagnosis ... #management #hematology
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