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diagnosis causes hepatology dermatology lfts systemic transaminitis gallbladder generalized management neurology pruritus thickening aclf acutekidneyinjury aki aortic chemistry cirrhosis ddxof
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... Injury (DILI) ... or symptoms of liver ... Drug #induced #Liver ... #algorithm #gastroenterology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Injury (DILI) - ... Alcohol-related liver ... dechallenge • Acute ... #DrugInduced #Liver
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Liver Failure ( ... Injury (DILI) ... #Chronic #Liver ... Cirrhosis #Hepatology #gastroenterology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Liver Injury: ... Liver Injury: ... • Iatrogenic: DILI ... Liver Injury:
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Cirrhosis • Chronic ... Hepatopathy • Acute ... (>1000): • DILI ... (Drug-induced liver
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Liver Failure ( ... > 2 • NASH, Chronic ... > 3 • Chronic ... chemistry #diagnosis #differential
Causes of Gallbladder Wall Thickening Primary Wall Thickening: 1 . Acute calculous cholecystitis 2. Acute acalculous cholecystitis 3. Chronic cholecystitis 4.
Chronic cholecystitis ... Adenomyomatosis Secondary ... Systemic Processes: Liver ... Typhoid, Dengue fever ... Thickening #Causes #differential
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Hepatocellular - Liver ... Artery: Shock Liver ... #Injury #Differential ... #algorithm #hepatology
Causes of Secondary IgA Nephropathy - Differential Diagnosis Algorithm • GI disorders: Celiac disease, Crohn's disease,
Causes of Secondary ... Nephropathy - Differential ... Diagnosis Algorithm ... Ulcerative Colitis • Liver ... Infections: H pylori, Chronic
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... > 20x normal - Acute ... 5-10x normal - Chronic ... #Patterns #Liver ... transaminitis #differential
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