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diagnosis hepatology causes lfts transaminitis aclf acutekidneyinjury aflp aki bleed chemistry chronic cirrhosis criticalcare drug druginduced failure fatty function gastrointestinal
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... Injury (DILI) ... or symptoms of liver ... Drug #induced #Liver ... #algorithm #gastroenterology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Liver Failure ( ... disease, liver ... Injury (DILI) ... Cirrhosis #Hepatology #gastroenterology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Liver Injury: ... Liver Injury: ... • Iatrogenic: DILI ... Liver Injury:
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Injury (DILI) - ... Alcohol-related liver ... dechallenge • Acute ... #DrugInduced #Liver
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Hepatopathy • Acute ... (>1000): • DILI ... (Drug-induced liver ... injury) • Ischemic
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Liver Failure ( ... ALF): • Liver ... - Specific to liver ... chemistry #diagnosis #differential
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Hepatocellular - Liver ... Artery: Shock Liver ... #Injury #Differential ... #algorithm #hepatology
Upper GI Bleed - Management Algorithm Upper GI bleed Suspected: Melena, hematemesis, coffee-ground emesis, BRBPR Initial Stabilization Concern for
Algorithm Upper ... Stabilization Concern for Liver ... GAVE (idiopathic, liver ... UGIB #GIBleed #Differential ... #gastroenterology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... liver failure rapidly ... Transfer to a liver ... #AFLP #Fatty #Liver
Hypocalcemia - Diagnosis and Management PTH Independent (↑ PTH) • LOW VIT D -
Diagnosis and Management ... - Activation: Liver ... Hypocalcemia #Diagnosis #Management ... #endocrinology ... #differential #algorithm
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