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diagnosis hepatology injury management acutekidneyinjury aflp aki bleed celiac chemistry clinicopathology ddxof drug druginduced em euvolemic fatty gastrointestinal gi gibleed
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... or symptoms of liver ... disease 6-9 mo ... Drug #induced #Liver ... #algorithm #gastroenterology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... for alternative causes ... disease, Hepatic ... dechallenge • Acute ... disorder (e.g. ascites
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Vascular Causes ... of Acute Liver ... • Iatrogenic: DILI
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
Causes of Ascites ... Liver disease ... fibrosis - Acute ... fatty liver of ... #differential #
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Hepatocellular Level ... disease: > 2 ... chemistry #diagnosis #differential ... transaminitis #LFTs
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Causes of Ascites ... - Differential ... Diagnosis Algorithm ... • Infiltrative disease ... • Acute liver
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... Hepatocellular - Liver ... Artery: Shock Liver ... #Acute #algorithm
Upper GI Bleed - Management Algorithm Upper GI bleed Suspected: Melena, hematemesis, coffee-ground emesis, BRBPR Initial Stabilization Concern for
Stabilization Concern for Liver ... GI ± EGD Causes ... GAVE (idiopathic, liver ... UGIB #GIBleed #Differential ... gastrointestinal #gastroenterology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... liver failure rapidly ... develops (DIC, ascites ... Transfer to a liver
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Hypertension - Differential ... of portal HTN: ascites ... • Cirrhosis/acute ... sarcoidosis) • Liver ... metastasis • Fatty liver
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