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diagnosis hematology causes management abnormal bleeding bruising hepatology prolonged pt rheumatology activation arterial bleed chemistry dic disseminated embolism gastrointestinal gi
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... unfractionated heparin ... Reduced liver synthesis ... Causes #diagnosis #differential ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
dysfunction (25%) • Hepatic ... DIC • Severe Liver ... 100mg/dL) - Heparin ... INR < 2.3 - APTT ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... • Reduced liver ... #hematology #coagulation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Bleeding / Bruising - Differential ... Diagnosis Algorithm ... Iatrogenic) • Liver ... #Diagnosis #Algorithm ... #Causes #Hematology
Upper GI Bleed - Management Algorithm Upper GI bleed Suspected: Melena, hematemesis, coffee-ground emesis, BRBPR Initial Stabilization Concern for
Stabilization Concern for Liver ... GI Bleed: • Peptic ... GAVE (idiopathic, liver ... UGIB #GIBleed #Differential ... gastrointestinal #gastroenterology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Acquired: • Heparin ... deficiency • Liver ... suggests liver ... these causes are liver ... Acquired: • Liver
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... • Albumin • Coagulation ... replaced by non-hepatic ... disease: > 2 • NASH ... chemistry #diagnosis #differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... Injury: • Hepatic ... Venoocclusive disease • Hepatic ... #diagnosis #algorithm
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
- Differential ... Diagnosis Algorithm ... Red Flags: • Fever ... Complete blood count coagulation ... #Causes #dermatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... deficiency • Liver ... Cholesterol emboli • Septic ... Vasculopathy #Purpura #Differential ... #nonpalpable #dermatology
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