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Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... Presentation: • Fever ... recurrent infections/fevers ... and petechiae Causes ... index < 2 • EPO Level
Faget's Sign & Liebermeister's Rule Pulse-Temperature Dissociation EVERY 1 F RISE IN TEMPERATURE -> HR INCREASES 8-10 BPM INFECTIOUS
• Typhoid Fever ... • Drug Fever ... CLINICAL UTILITY ... Typhoid Fever (S ... Dengue Fever NOTE
Faget Sign - Pulse-Temperature Dissociation Causes of Relative Bradycardia • Infectious Causes: Legionella, Psittacosis, Q fever, Typhoid
Psittacosis, Q fever ... , Typhoid fever, ... , Dengue fever, ... Mountain spotted fever ... , Drug fever
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... Non-Infectious Causes ... disease • Behcet's syndrome ... • Hyper-IgD syndrome ... receptor-associated periodic syndrome
Causes of Relative Bradycardia - Note the propensity for intracellular organisms. Infectious: Legionella, Psittacosis, Q fever, Typhoid
Causes of Relative ... , Typhoid fever, ... , Dengue fever, ... , Drug fever ... #bradycardia #Causes
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Causes of Fever ... Lemierre's syndrome ... Brucellosis, Q fever ... Mediterranean fever ... , Factitious fever
Differential Diagnosis - Noninfectious Causes of Fever CRITICAL DIAGNOSES: - Acute myocardial infarction - Pulmonary embolism or
Noninfectious Causes ... of Fever CRITICAL ... DIAGNOSES - Drug fever ... #Fever #Noninfectious ... #Causes #Differential
Childhood Immunization Schedule: Why we immunize • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
pharyngeal erythema, fever ... pharyngeal erythema, fever ... attack meninges -> Fever ... Sudden onset of fever ... pruritic rash, fever
Causes of Fever by System #Diagnosis #EM #IM #Fever #Differential #Ddxof
Causes of Fever ... Diagnosis #EM #IM #Fever
Bradycardia - Differential Diagnosis Framework BRADI Mnemonic • BRASH/Hyperkalemia • Reduced oxygen/Glucose/Temp • ACS • Drugs •
Diptheria • Typhoid fever ... Acute rheumatic fever ... Psittacosis • Q fever ... • Yellow fever ... differential #diagnosis #causes
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