21 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... or symptoms of liver ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Tests (LFTs) - ... Differential Diagnosis ... (>1000): • DILI ... #Differential # ... Diagnosis #hepatology
Evaluation abnormal liver tests in pregnancy
- Cholestatic Pattern
- Hepatocellular Pattern

#LFTs #transaminits #pregnancy #obgyn #obstetrics #hepatology #diagnosis
Evaluation abnormal liver ... Hepatocellular Pattern #LFTs ... obgyn #obstetrics #hepatology ... #diagnosis #differential ... #algorithm
The Liver Consult Primer - Guide to calling a consult
HPI:
 - Start with reason for consult
- Vitals - LFTs ... GTT, indirect bili ... biopsy Meds: ... - Outpatient meds ... Calling #Referral #Hepatology
Erythematous Rashes - THE ALGORITHMIC APPROACH

Characterized by diffuse redness of the skin due to
capillary congestion, erythematous
or absence of fever ... If fever is present ... disease, scarlet fever ... but without a fever ... #Febrile #Fever
Vesiculobullous Rashes - THE ALGORITHMIC APPROACH 
Vesiculobullous rashes provoke significant angst
in many physicians (Figure 5, page
Vesiculobullous Rashes - THE ALGORITHMIC ... and a fever may ... localized lesions and fever ... #Diagnosis #Dermatology ... #Algorithm #Differential
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... disease: > 2 • NASH ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... normal - Hemolysis, NASH ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... Diagnosis Algorithm ... • Others #LFTs ... #Hepatology #LiverEnzymes
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Diagnosis Algorithm ... disease: > 2 • NASH ... #diagnosis #algorithm ... #hepatology