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diagnosis causes oncology treatment anemia ascites dermatology rheumatology activation algorithm anesthesia anesthesiology aplastic apml checklist cirrhosis classification differentiation dress gap
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... #Diagnosis #Management ... #Hematology #Rheumatology
Ascites Management Principles Low Salt Diet - 2000 Mg Sodium Fluid Restriction - Never Work-horse Diuretic - Aldosterone Antagonist Combination
Ascites Management ... Restriction - Never ... Work-horse Diuretic ... ebtapper #Ascites #Management ... #cirrhosis #hepatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... mountain spotted fever ... #Diagnosis #hematology
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
- Budd-Chiari syndrome ... - Nephrotic syndrome ... Mediterranean fever ... Causes #diagnosis #differential ... #hepatology #SAAG
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... bartonella (oroya fever ... Hemolytic #Anemia #Differential ... Diagnosis #Algorithm #workup ... #hematology #testing
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... recurrent infections/fevers ... index < 2 • EPO Level ... Anemia #oncology #hematology ... #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... hyperviscosity syndrome ... - 80% have fever ... TLS #diagnosis #management ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Subacute-Acute: • Common: fever ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... following: • Fever ... lymph node, or liver ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia If prolonged or ≥ 39 C this is a
Actively maintained fever ... • Serotonin syndrome ... #Hyperthermia #Differential ... Checklist #Diagnosis #Management ... #Workup
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