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Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Hyperthyroidism Fever ... • Rheumatic fever ... SLE, Rheumatic fever ... stenosis - Rheumatic fever ... • New murmur, fever
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... #Diagnosis #Management ... #Hematology #Rheumatology
Campylobacter
Clinical 
 • Fever 
 • Abdominal pain 
 • Diarrhea (bloody stools) 
 • Vomiting
Clinical • Fever ... • Abdominal pain ... Guillain-Barré syndrome ... Management ... Antibiotics for severe disease
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint Pain ... • Rheumatic fever ... Antiphospholipid-antibody syndrome ... dermatology #joint #pain ... differential #diagnosis #rheumatology
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
Hyperviscosity Syndrome ... death Neutropenic Fever ... New-onset back pain ... Chest and shoulder pain ... Dyspnea, chest pain
Red Flags in Back Pain
 • Cancer: Age > 50, History of cancer, Unexplained weight loss,
Flags in Back Pain ... • Infection: Fever ... • Cauda equina syndrome ... RedFlags #Back #Pain ... #primarycare #checklist
Diagnostic criteria for Neutropenic Enterocolitis (NEC)
Major Criteria:
 • Neutropenia (ANC <500 x 10^9 cells/L)
 • Bowel
30mm length) • Fever ... • Abdominal pain ... Diagnosis #criteria #hematology ... #oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
- Pel-Ebstein fever ... Alcohol-induced pain ... : Pain in involved ... NonHodgkins #comparison #oncology ... #differential #hematology
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
Inflammatory Joint Pain ... Early Rheumatic Disease ... • Rheumatic Fever ... Sicca) Syndrome ... • Rheumatic Fever
Pancreatitis management checklist 
Evaluation to guide etiology & management 
 - RUQ ultrasound 
 - Calcium
checklist Evaluation ... abdominal compartment syndrome ... Pain control - ... gram Q6hr) and pain-dose ... #Pancreatitis #Checklist