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diagnosis dermatology differential management rheumatology systemic generalized hemeonc oncology activation emergencies hemophagocytic hlh leukemia lymphohistiocytosis macrophage mas naildisorders nonpalpable oncologic
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Pruritus - Generalized ... Diabetes Mellitus Liver ... • Cholestatic liver ... Myelodisplastic syndrome ... #primary #secondary
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Diabetes Mellitus Liver ... • Cholestatic liver ... Myelodisplastic syndrome ... #secondary #systemic ... #causes
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
leakage of RBC's secondary ... Kasabach-Merritt syndrome ... deficiency • Liver ... mountain spotted fever ... Differential #Diagnosis #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Classified among the secondary ... disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... thrombocytopenia • Liver
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... discoloration) • Liver ... • Nephrotic syndrome ... #Diagnosis #Algorithm ... #causes
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Neutropenic fever ... : - Fever + ANC ... ): - Hematologic ... or HSCT - CRS: fever ... therapy - Symptoms: fever
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... sweats, bleeding • Pruritis ... • Tumor lysis syndrome ... bone marrow and secondary ... #Leukemia #Hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
other diseases • Secondary ... Hypocomplementemia • Can cause ... vasculitis: 10%-16% Liver ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
caused by uncontrolled ... Characteristics: Persistent fever ... Persistent high fever ... - Elevated liver ... Fever b.
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