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diagnosis management syndrome dermatology hemophagocytic hlh lymphohistiocytosis reactions blood comparison differential disease hemeonc hodgkins lymphoma product transfusion 2ndline activation adult
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
• Secondary Causes ... deficiency • Liver ... mountain spotted fever ... Differential #Diagnosis #hematology ... #rheumatology #
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... - Nonremitting fever ... thrombocytopenia • Liver ... Diagnosis #Management #Hematology ... #Rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Daily high spiking fever ... - Fever spikes ... Fever of at least ... /splenomegaly, liver ... AOSD #diagnosis #rheumatology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
without other cause ... explain symptoms • Fever ... : 33% • Treatment ... pulmonary edema) • Fever ... Transfusion #Reactions #hematology
Kawasaki Disease (KD) - Diagnosis and Management Summary Kawasaki Disease (KD) is the most common vasculitis of
Presentation: • Fever ... , Cough • +/-Nausea ... Diagnostic Criteria - Fever ... KD #vasculitis #rheumatology ... diagnossi #management #treatment
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
- Pel-Ebstein fever ... the spleen or liver ... Lymphomas • Other hematologic ... NonHodgkins #comparison #oncology ... #differential #hematology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
Dermatomyositis • Fever ... disease and ILD • Liver ... Liver biopsies show ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
following: • Fever ... lymph node, or liver ... • Bicytopenia Treatment ... diagnosis #management #treatment ... #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Neutropenic fever ... : - Fever + ANC ... Treat underlying cause ... or HSCT - CRS: fever ... therapy - Symptoms: fever
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... , ↓ Fibrinogen level ... Treatment: • ... diagnosis #management #treatment ... #summary #rheumatology
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