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Kawasaki Disease (KD) - Diagnosis and Management Summary

Kawasaki Disease (KD) is the most common vasculitis of
Kawasaki Disease ... Presentation: • Fever ... cæxist with other infections ... Diagnostic Criteria - Fever ... #rheumatology #pediatrics
Multi-System Inflammatory Syndrome in Children (MIS-C) vs. Kawasaki Disease
CDC Case Definition for MIS-C;
 • < 21
Kawasaki Disease ... CDC Case Definition ... years old with fever ... other reasons for disease ... diagnosis #peds #pediatrics
Kawasaki Disease - Timeline of Clinical Features and Complications
 - Fever >5 days 
 - 4
Kawasaki Disease ... - Timeline of Clinical ... Complications - Fever ... - Conjunctival infection ... Symptoms #Peds #Pediatrics
Mucocutaneous Findings Kawasaki’s Disease - Patients present with diffuse red rash and fever with lymphadenopathy, strawberry
’s Disease - Patients ... diffuse red rash and fever ... #Clinical #Peds ... #Pediatrics #Kawasaki ... #Disease #Rash
MIAMI Mnemonic for Differential Diagnosis of Lymphadenopathy
Malignancies
 - Kaposi sarcoma, leukemias, lymphomas, metastases, skin neoplasms
Infections
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skin neoplasms Infections ... chancroid, cutaneous infections ... tularemia, typhoid fever ... histiocytosis, Kawasaki ... sarcoidosis Iatrogenic causes
Causes of Myocarditis 
1. Infectious Myocarditis
 • Bacterial - Staphylococcus, Streptococcus, Pneumococcus, Meningococcus, Gonococcus, Salmonella, Corynebacterium
Coxiella bumetti (Q fever ... Mountain Spotted fever ... virus, yellow fever ... Junin virus, Lassa fever ... (rheumatic fever
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... : fever +++, hepatosplenomegaly ... , ↓ Fibrinogen level ... Treatment: •
Bradycardia - Differential Diagnosis Framework

BRADI Mnemonic
 • BRASH/Hyperkalemia
 • Reduced oxygen/Glucose/Temp
 • ACS
 • Drugs
 •
Drugs • ICP / Infections ... Diptheria • Typhoid fever ... Acute rheumatic fever ... Psittacosis • Q fever ... • Yellow fever
Adjuvant therapies in critical care: steroids to treat infectious diseases
 - Severe Community Acquired Pneumonia
Adjuvant therapies in critical ... steroids to treat infectious ... diseases - Severe ... Pneumonia - Typhoid fever ... Pharmacology #Management #Treatment
Hantavirus
Pathogen: Hantavirus - Rodents are the primary reservoir
Transmission:
 • Shed in the urine, feces, saliva of
common route of infection ... • Prodrome: fever ... • Autopsy PCR Treatment ... diagnosis #management #treatment ... #microbiology #