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diagnosis oncology differential activation aplastic cardiology causes classification differentiation endocarditis hodgkins immune infectiousdiseases inflammatory iris leukemia leukostasis lung lymphoma lysis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Subacute-Acute: • Common: fever ... common • Imaging: CXR ... #management #hematology
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
: • 80% have fever ... Leukocytosis, anemia ... Blood cultures • CXR ... early disease) • CXR ... decubitus - air fluid level
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... with leukopenia, anemia ... #Hematology #Rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... recurrent infections/fevers ... Treatment: ... #oncology #hematology ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... manifestations, hypoxia, CXR ... - infiltrates (anemia ... smear: Blasts APML ... #Leukemia #Hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... - 80% have fever ... organ damage • Treatment ... TLS #diagnosis #management ... #hematology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... osteomyelitis, cutaneous abscesses ... - Pneumonitis (fever ... Fever, chills, lack ... Differential #Diagnosis #Management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... Weight loss • Anemia ... Hodgkin Lymphoma Treatment ... classification #hematology ... #oncology #management
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
night sweats, fever ... Cholesterol emboli syndrome ... Leukocytosis, anemia ... hematuria, + RF Treatment ... Persistent bacteremia/fevers
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