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management hematology differential causes syndrome leukemia radiologyassistant chronic clinical consolidation diffuse hemophagocytic hlh hodgkins latenttb lobar lymphocytic lymphohistiocytosis lymphoma pulmonary
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... Tyrosine Kinase activity ... Headaches, bone pain, fever ... manifestations, hypoxia, CXR ... #Oncology #Diagnosis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
- Pel-Ebstein fever ... Differential Diagnosis ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Differential diagnosis The table summarizes the most common diseases, that present with consolidation. Chronic diseases are indicated in
Differential diagnosis ... usually multiple ill-defined ... respond to the treatment ... #Diagnosis #Radiology ... #Pulmonary #CXR
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
: • 80% have fever ... Blood cultures • CXR ... ) • CXR upright ... decubitus - air fluid level ... Intervention: - Fevers
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... cells can indicate disease ... microglobulin Treatment ... #workup #oncology ... #hematology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
correlates with time of fever ... Daily high spiking fever ... - Fever spikes ... Fever of at least ... activity!
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... - Differential Diagnosis ... Encapsulated Bacteria Cell ... • Periodontal Disease ... Infection #Fever
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... • Induce blast cell ... Subacute-Acute: • Common: fever ... common • Imaging: CXR ... #oncology
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
with passive AND active ... ROM +/- fever, ... necrosis, Lyme disease ... Treatment: admission ... cervical, anal Cxs
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... following: • Fever ... Low or absent NK cell ... activity • Ferritin ... #hematology
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