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diagnosis hematology management anemia aplastic chronic cll differentiation emergencies hemeonc lymphocytic oncologic syndrome workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... Headaches, bone pain, fever ... smear: Blasts APML ... Lymphadenopathy • HSM • Fevers ... #Hematology #Oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... Renal Failure Treatment ... Differentiation #Syndrome #APML ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... microglobulin Treatment ... Transform to DLBCL, PML ... diagnosis #workup #oncology ... #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Neutropenic fever ... : - Fever + ANC ... interventional radiology ... or HSCT - CRS: fever ... therapy - Symptoms: fever
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... recurrent infections/fevers ... virus (EBV) • Leukemia ... aplastic anemia Treatment ... Aplastic #Anemia #oncology
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