39 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... Headaches, bone pain, fever ... , joint pain, bleeding ... , weight loss, abdominal ... #Oncology #Diagnosis
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
acute rheumatic fever ... • Chronic - Think ... ), RA, crystal disease ... Send for cell count ... #rheumatology #
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
e.g., HIV), EBV infection ... - Pel-Ebstein fever ... Etiology: - Infections ... NonHodgkins #comparison #oncology ... #differential #hematology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Hyperthyroidism Fever ... • Rheumatic fever ... SLE, Rheumatic fever ... stenosis - Rheumatic fever ... • New murmur, fever
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint ... parvovirus B19 infection ... parvovirus B19 infection ... Dermatomyositis Erythema chronicum ... • Rheumatic fever
Acute and Chronic Causes of Dyspnea - Differential Diagnosis
Pulmonary/Chest Wall:
 • Acute: Trauma, COPD exacerbation, Asthma
, Anaphylaxis, Infection ... dysfunction, Goiter Abdominal ... Ascites, Intra-abdominal ... poisoning, DKA, Fever ... Depression - VA Joint
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Infections 2. ... symptoms - Headache, fever ... fatigue, Nausea, abdominal ... , Chronic spontaneous ... urticaria, Chronic
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... weeks without infection ... cells can indicate disease ... microglobulin Treatment ... #hematology
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... : High spiking fever ... Systemic AOSD: high fever ... arthritis and chronic ... #AOSD #rheumatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... in those with CLD ... months without treatment ... disease, liver ... Coagulation Failure Infections