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diagnosis differential acute causes hematology treatment gastroenterology kidney aclf activation chemistry chronic cirrhosis classification colitis common criticalcare cvid drug druginduced
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... Injury (DILI) ... or symptoms of liver ... disease 6-9 mo ... Drug #induced #Liver
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Injury (DILI) - ... Alcohol-related liver ... disease, Hepatic ... #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... disease, liver ... support, or liver ... Injury (DILI) ... Failure #Cirrhosis #Hepatology
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Acute Kidney Injury ... a.k.a. cardiorenal syndrome ... ) • Liver failure ... a.k.a. hepatorenal syndrome ... causes: sepsis, meds
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Myelodysplastic Syndromes ... WBCs - Normal Liver ... Deficiency - Abnormal Liver ... Tests • Liver ... #Causes #Hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... of cholestatic disease ... disease: > 2 ... • Gilbert's syndrome ... #differential #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute Liver ... Hepatocellular - Liver ... obstruction, HELLP Syndrome ... Artery: Shock Liver ... #hepatology
Acute Kidney Injury (AKI) - Management Principles Prerenal - Correct hemodynamic derangements: • If low preload →
Acute Kidney Injury ... (AKI) - Management ... • Hepatorenal syndrome ... Treat underlying liver ... disease, ?
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... with leukopenia, anemia ... thrombocytopenia • Liver ... #Diagnosis #Management ... #Hematology #Rheumatology
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