11 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Syndrome and Acute ... Pregnancy (AFLP) ... Three syndromes ... #AFLP #obstetrics ... #hematology #diagnosis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Wilsons, Pregnancy - AFLP ... , HELLP • Moderate ... Burak @kwburak #LFTs ... Algorithm #diagnosis #hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
, no necrosis HELLP ... Syndrome (Hemolysis ... of Pregnancy (AFLP ... Disease #Pregnancy #hepatology ... #AFLP
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Pregnancy - AFLP ... , HELLP Moderate ... • Others #LFTs ... #Hepatology #LiverEnzymes
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... Hepatocellular Level ... replaced by non-hepatic ... • Gilbert's syndrome ... #differential #Hepatology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... coagulation defects. 1) HELLP ... Pregnancy #TTPHUS #HELLP ... #AFLP #Obstetrics ... #OBGyn #Hematology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... Antithrombin Ill • Ultrasound ... Preeclampsia, HELLP ... iMedEducation #AFLP ... Pregnancy #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Injury: • Hepatic ... vein: Budd-chiari syndrome ... Venoocclusive disease • Hepatic ... • Pregnancy: HELLP ... diagnosis #algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
biliary obstruction, HELLP ... Syndrome, Celiac ... Vasculature • Hepatic ... Congestion/CHF • Hepatic ... Acute #algorithm #hepatology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
presence of metabolic syndrome ... ALP, alkaline phosphatase ... mellitus; USS, ultrasound ... #LFTs #Abnormal ... #Algorithm #Hepatology