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diagnosis differential injury transaminitis algorithm management nephrology syndrome aclf chemistry classification clinical dili diuresis diuretics druginduced encephalopathy excretion failure function
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... • NAFLD • Cirrhosis ... • Chronic Viral ... Hepatopathy • Acute ... (Drug-induced liver
Flapping tremors of Asterixis DDx - Decompensated cirrhosis or acute liver failure. - Renal failure /azotemia. - Respiratory failure with
Flapping tremors of Asterixis ... Decompensated cirrhosis ... or acute liver ... hyperammonemia #PhysicalExam ... clinical #diagnosis #video
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 Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Liver Failure ( ... months without treatment ... #Chronic #Liver ... #Hepatology #gastroenterology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... > 20x normal - Acute ... CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... #Patterns #Liver
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... > 2 • NASH, Chronic ... hepatitis: < 1 • Cirrhosis ... #differential #Hepatology ... transaminitis #LFTs
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... for alternative causes ... Alcohol-related liver ... dechallenge • Acute ... #DrugInduced #Liver
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Algorithm Vascular Causes ... of Acute Liver ... hepatitis: < 1 • Cirrhosis ... diagnosis #algorithm #hepatology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
heart failure, liver ... cirrhosis, chronic ... heart failure, liver ... cirrhosis, chronic ... cirrhosis, chronic
Hepatic Encephalopathy - Diagnosis and Management Summary Definition: • Alteration in brain function manifested by neuropsychiatric symptoms
neuropsychiatric symptoms • Caused ... by liver insufficiency ... Prevalence: At cirrhosis ... Personality change, Asterixis ... #hepatology
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
liver disease characterized ... liver disease ... DIAGNOSIS - TRIAD: • Liver ... the severity of liver ... supplemental oxygen • Liver
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