31 results
Drugs and Classes Associated with DILI and Type of Liver Injury

#Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... and Type of Liver ... #LiverInjury #Hepatology ... #Pharmacology # ... Causes #DILI
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... Injury - Pathophysiology ... BrighamChiefs #DILI ... #Injury #Pathophysiology ... #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... or symptoms of liver ... Drug #induced #Liver ... #differential #Diagnosis ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis ... Algorithm DILI ... #Injury #Diagnosis ... #Algorithm #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... - Differential Diagnosis ... (>1000): • DILI ... #Differential #Diagnosis ... #hepatology #transaminitis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... 10x ULN), ↑Tbili/Dbili ... Antithrombin Ill • Ultrasound ... ) Differential Diagnosis ... #Pregnancy #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... disease, liver ... Injury (DILI) ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
- Differential Diagnosis ... Trauma: Shock liver ... • Iatrogenic: DILI ... #Differential #Diagnosis ... #causes #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... • Iatrogenic: DILI ... Unconjugated Bili ... #differential #diagnosis ... #algorithm #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... abnormality vs bone Bili ... Transaminitis #diagnosis ... #hepatology