9 results
Drugs and Classes Associated with DILI and Type of Liver Injury

#Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... and Type of Liver ... #LiverInjury #Hepatology ... #Pharmacology # ... Causes #DILI
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... Injury - Pathophysiology ... BrighamChiefs #DILI ... #Injury #Pathophysiology ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... (>1000): • DILI ... (Drug-induced liver ... Differential #Diagnosis #hepatology ... #transaminitis
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Transaminases / Transaminitis ... Trauma: Shock liver ... • Iatrogenic: DILI ... images/10587 #Transaminitis ... Diagnosis #causes #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... abnormality vs bone Bili ... LFTs #Elevation #Transaminitis ... #diagnosis #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... 10x ULN), ↑Tbili/Dbili ... Antithrombin Ill • Ultrasound ... #Pregnancy #hepatology ... diagnosis #management #pathophysiology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Hepatocellular Level ... Unconjugated Bili ... > 90% of Total Bili ... #differential #Hepatology ... #transaminitis
Nutrition in Cirrhosis: Dos and Don’ts
Screening:
 • Patients at risk for RFH-Nutritional Prioritizing Tool
 • Low
) • Advanced liver ... Analysis, muscle ultrasound ... patients with liver ... diet #management #hepatology ... #pathophysiology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Occurs in advanced liver ... Pathophysiology: ... Normal kidney ultrasound ... • Urgent liver ... Hepatorenal #Syndrome #Hepatology