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diagnosis liver management algorithm differential transaminitis dili hbv hepatitis hepatitisb aclf acute aih autoimmune bloodsmear borrelia calling chemistry classification clinical
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... • NAFLD • Cirrhosis ... • Chronic Viral ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Injury (DILI) ... #Cirrhosis #Hepatology ... #gastroenterology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
presentation • Chronic ... - ongoing ↑ LFTs ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Injury Transaminase ... CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... #Injury #hepatology ... #LFTs #transaminitis
The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
Gl History - Cirrhosis ... - Vitals - LFTs ... current MELD - Chronic ... Calling #Referral #Hepatology ... #Gastroenterology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Hepatocellular Level ... hepatitis: < 1 • Cirrhosis ... : > 3 • Chronic ... #differential #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... non-essential drug/HDS treatments ... dechallenge • Acute or chronic ... e.g. ascites), Chronic ... #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... > 2 • NASH, Chronic ... hepatitis: < 1 • Cirrhosis ... : > 3 • Chronic ... diagnosis #algorithm #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... treat the pts with chronic ... viremia or have cirrhosis ... Diagnosis #Management #Treatment ... #Hepatology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Family history of cirrhosis ... or fibrosis • Cirrhosis ... injury (INR > 2 ... mg/dL) or acute liver ... Indications #management #hepatology
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