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diagnosis management differential infections oncology adjuvant aids anemia antibiotic antimicrobials antipseudomonal antipseudomonas aplastic associated capd cardiology colistin corticosteroids csf emergencies
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
: • Most CNS opportunistic ... • CNS opportunistic ... Antimicrobial treatment ... • Symptoms: Fever ... #InfectiousDiseases
Adjuvant therapies in critical care: steroids to treat infectious diseases - Severe Community Acquired Pneumonia
Pneumonia - Typhoid fever ... respiratory distress syndrome ... Corticosteroids #Adjuvant #InfectiousDiseases ... #Infections #Pharmacology ... #Management #Treatment
Causes of Antibiotic Failure - Differential Diagnosis Framework Diagnosis: • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
NMS, serotonin syndrome ... Immunocompromise Treatment ... Tissue penetration (CNS ... • Secondary to Treatment ... SJS, DIHS, drug fever
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... - Overview of IRIS ... decrease in HIV-1 RNA level ... pleural effusions, CNS ... #Inflammatory #Syndrome
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia - Overview ... Presentation: • Fever ... - β-lactam antibiotics ... index < 2 • EPO Level ... aplastic anemia Treatment
CAPD-associated peritonitis (Continuous Ambulatory Peritoneal Dialysis) - 5 Things To Know Diagnosis (Two of the following): (1) Clinical
culture Note that fever ... positive (60% CONS ... diverticulitis) Treatment ... • Prophylactic antibiotics ... Diagnosis #Management #InfectiousDiseases
CSF Penetration of Antimicrobials Despite the poor CSF penetration, beta-lactams have the most research documenting successful treatment
documenting successful treatment ... compared to other antibiotic ... FDA-approved for UTI treatment ... Antimicrobials #InfectiousDiseases ... #Pharmacology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Overview Epidemiology ... • 8%-27% for CNS ... vasculitis: 10%-16% Liver ... Adenocarcinoma Treatment ... lubricants • Pharmacologic
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
500 → may stop antibiotics ... ) - Symptoms: CNS ... → no immediate treatment ... ICANS: altered level ... ) - Treatment:
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Endocarditis - Overview ... Cholesterol emboli syndrome ... hematuria, + RF Treatment ... • IV antibiotics ... Diagnosis #cardiology #infectiousdiseases
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