12 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
) Pathophysiology ... Phagocytosis of blood ... , ↓ Fibrinogen level ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: HLH signs and ... following: • Fever ... lymph node, or liver ... #management #treatment ... #hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Cirrhosis (PBC) - Summary ... 65 years PBC Pathophysiology ... cholestasis → Cirrhosis/Liver ... failure PBC Signs ... or higher • Liver
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... Presentation • Common Signs ... - Elevated liver ... Pathophysiology ... #Management #Hematology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Summary - GrepMed ... malignancy Pathophysiology ... GH stimulates liver ... • Serum IGF-1 level ... adenoma, ↓(TFT, LH
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Summary Epidemiology ... survival is 93-95% Pathophysiology ... anterior/posterior MSK ... heart (2-5%), liver ... #Management #Signs
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
One Pager Summary ... donors (due to anti-HLA ... eruptions, diarrhea, liver ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... donors (due to anti-HLA ... eruptions, diarrhea, liver ... #Transfusion #diagnosis ... #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
ABO incompatible blood ... protein C and S Pathophysiology ... DIC • Severe Liver ... #Coagulation #diagnosis ... causes #treatment #management
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
and Management ... Summary 3 Conditions ... double contour sign ... +Radiographic signs ... #rheumatology