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hematology syndrome differential causes disease hemophagocytic lymphohistiocytosis product reactions abscess acromegaly activation algorithm bacterial calcium chagas classification coagulation cppd criticalcare
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
) Pathophysiology ... Phagocytosis of blood ... , ↓ Fibrinogen level ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: HLH signs and ... lymph node, or liver ... • Bicytopenia Treatment ... #management #treatment ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
thrombocytopenia • Liver ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Summary A defect ... the setting of liver ... • Underlying liver ... hypertension • Liver ... #management #treatment
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
Summary - GrepMed ... GH stimulates liver ... • Serum IGF-1 level ... adenoma, ↓(TFT, LH ... #Treatment #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... - 80% have fever ... WBC >100k, + lab signs ... Syndrome #TLS #diagnosis ... #management #hematology
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Summary Lung ... Lung Abscess Pathophysiology ... anemia • Sputum/Blood ... decubitus - air fluid level ... #treatment #diagnosis
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Summary Epidemiology ... survival is 93-95% Pathophysiology ... anterior/posterior MSK ... heart (2-5%), liver ... #Management #Signs
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... protein C and S Pathophysiology ... DIC • Severe Liver ... #Coagulation #diagnosis ... #management #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... Workup: • Full Blood ... marrow biopsy - if blood ... Hodgkin Lymphoma Treatment ... #oncology #management
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