15 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
is the main clinical ... ALT ↑ bilirubin level ... Fibrin degradation products ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
B for initial management ... - Virtually never ... infections) - Main ... adverse effects = Hematologic ... #Pharmacology #Antibiotics
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Crystal induced (Gout ... - Autoimmune Rheumatologic ... • Lyme • Gout ... Differential #Diagnosis #MSK ... #rheumatology #
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
and Management ... swelling, significant pain ... Dual-energy CT → MSU ... • Serum urate level ... #treatment #rheumatology
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
and fingers, or pain ... responsive to antibiotics ... 9) Unexplained fever ... has been ruled out ... erythematosus #rheumatology
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
Pyrophosphate produced ... onset of swelling, pain ... 12-24 Hours • Fever ... swelling, significant pain ... #Comparison #rheumatology
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Approach to Joint Pain ... acute rheumatic fever ... reactive arthritis, gout ... #Joint #Pain #MSK ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
following: • Fever ... rapidly, and empiric antibiotic ... agent are the main ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Special Blood Product ... pain, dark urine ... Transfusions #diagnosis #management ... #hematology #reactions
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... activated macrophages produce ... Self-limiting, chronic but stable ... anterior/posterior MSK ... Sarcoidosis #Diagnosis #Management