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diagnosis management algorithm differential druginduced injury medications aclf acute aflp air alcoholic chronic cirrhosis clinical diuresis diuretics elevated excretion failure
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... and Type of Liver ... #LiverInjury #Hepatology ... #Pharmacology # ... Causes #DILI
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 Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... non-essential drug/HDS treatments ... for alternative causes ... Alcohol-related liver ... #Liver #Injury
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... months without treatment ... disease, liver ... Injury (DILI) ... Failure #Cirrhosis #Hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... • Autoimmune hepatitis ... • Iatrogenic: DILI ... Differential #Diagnosis #causes ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... , vomiting, abdominal ... malaise) → Acute liver ... Transfer to a liver
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... • Iatrogenic: DILI ... Chronic viral hepatitis ... #injury #hepatitis ... diagnosis #algorithm #hepatology
Portal venous gas on hepatic ultrasound: A concerning finding in the critically ill patient that should
gas on hepatic ultrasound ... ileus), intra-abdominal ... variety of other causes ... portal #venousgas #ultrasound ... #hepatology #liver
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 Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... >20) - Obtain abdominal ... exclude other causes ... HCV, DILI, HCC, ... Management #Algorithm #hepatology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
heart failure, liver ... heart failure, liver ... Kidney stones caused ... heart failure, liver ... heart failure, liver
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... vasculitis: 10%-16% Liver ... • Autoimmune hepatitis ... Adenocarcinoma Treatment ... lubricants • Pharmacologic
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