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Kawasaki Disease (KD) - Diagnosis and Management Summary

Kawasaki Disease (KD) is the most common vasculitis of
Kawasaki Disease ... Presentation: • Fever ... Diagnostic Criteria - Fever ... #rheumatology # ... #management #treatment
Erythematous Rashes - THE ALGORITHMIC APPROACH

Characterized by diffuse redness of the skin due to
capillary congestion, erythematous
or absence of fever ... If fever is present ... diagnosis includes Kawasaki ... disease, scarlet ... fever, and toxic
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
erythematosus • Kawasaki ... fever syndromes ... multiorgan failure • Fever ... - Nonremitting fever ... Treatment: • Corticosteroids
Kawasaki Disease - Timeline of Clinical Features and Complications
 - Fever >5 days 
 - 4
Kawasaki Disease ... Complications - Fever ... #Disease #Timeline ... #Features #Signs ... Symptoms #Peds #Pediatrics
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
correlates with time of fever ... Daily high spiking fever ... - Fever spikes ... Fever of at least ... #management
Evaluation of suspected incomplete Kawasaki Disease

1. AHA consensus recommendations
2. Infants ≤6 months old on day ≥7
old on day ≥7 of fever ... echo is positive, treatment ... within 10 d of fever ... clinical and lab signs ... #Kawasaki #Disease
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... an infant with fever ... #Pediatrics #Peds ... #Febrile #Infant ... Stratification #Fever
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Clinical triad: Fever ... autoinflammatory diseases ... #diagnosis #management ... #treatment #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... Diagnosis: HLH signs ... acute or subacute febrile ... following: • Fever ... #treatment #hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Illness Script Signs ... megaloblastic anemia Treatment ... if neutropenic fever ... Anemia #diagnosis #management ... #treatment #hematology