19 results
Immune Checkpoint Inhibitor Toxicity

Main Toxicities: Colitis,  
Pneumonitis, Skin adverse events, Endocrine dysfunction, 
Hepatitis,  
Myocarditis,
Checkpoint Inhibitor Toxicity ... Complications and Treatment ... CheckpointInhibitor #Toxicity ... Table #Diagnosis #Pharmacology ... #Oncology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... initiation • Differential ... Renal Failure Treatment ... #oncology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... fraction < 20% Differential ... diagnosis #management #treatment ... #rheumatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
the spleen or liver ... involvement Differential ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Testicular Cancer - Treatment Related Toxicities

Bleomycin, Cisplatin, Etoposide, lfosfamide
Tinnitus & Hearing Loss
Neurotoxicity
Pulmonary Fibrosis
Hypotension
Nephrotoxicity
Skin Hyperpigmentation
Hemorrhagic Cystitis
Myelosuppression
Peripheral Neuropathy

Ashley
Testicular Cancer - Treatment ... #chemotherapy #toxicity ... toxicology #Toxicities #pharmacology ... #oncology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
interactions) Cancer-treatment ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
patients who have treatment-resistant ... metabolized in the liver ... #Toxicology #Toxicity ... #Diagnosis #Pharmacology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Presentation: • Fever ... index < 2 • EPO Level ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Systemic Therapy for Hepatocellular Carcinoma - AGA Clinical Practice Guideline

First Line Treatment for HCC with Preserved
First Line Treatment ... with Preserved Liver ... Function Second Line Treatment ... Gastroenterology #oncology ... #Pharmacology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Reversible course Differential ... Medication/Drug toxicity ... elevated protein level ... persistent altered level ... epilepticus Treatment