48 results
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
KBinders #Kayexelate #Comparison ... #Table #Pharmacology ... #Patiromer #HyperKalemia ... #Nephrology #Agents
Considerations for Crystalloids - 0.9% NS vs LR vs Plasma-Lyte
 - Causes hyperkalemia?
 - Safe to
hyperkalemia? ... patients with hyperkalemia ... - Causes lactic ... #Crystalloids #pharmacology ... #indications #comparison
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
constipation, diarrhea, nausea ... Dosing: 15 g (4 level ... ); nausea, vomiting ... #medications #pharmacology ... #table #comparison
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Causes of Hypokalemia ... Defining the cause ... measuring urinary K level ... diagnosis #algorithm #causes ... #nephrology #potassium
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Management of Hyperkalemia ... Binders #Management #Hyperkalemia ... #treatment #pharmacology ... #table #comparison ... #nephrology
Characteristics of Commonly Used Phosphate Binders 
Aluminum 
 - Potent and effective 
 - Useful for
absorption - Lowers level ... edgarvlermamd - Nephrology ... Binders #Table #Comparison ... #Pharmacology # ... Nephrology
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Causes of Fatigue ... Renal Failure • Liver ... Failure • Hypercalcemia ... Pulmonary Disease Neurologic ... Myasthenia Gravis Pharmacologic
Migraine - Preventative Treatments

 • Anticonvulsants: *Topiramate, *Sodium valproate, Gabapentin, Pregabalin
 • Antidepressants: Amitriptyline, Venlafaxine, Duloxetine,
- Preventative Treatments ... Cyproheptadine * Level ... #Preventative #Treatment ... prophylaxis #prevention #pharmacology ... #neurology
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
production • Treatment ... rapidly fatal • Causes ... Identify underlying cause ... Cooling blankets can cause ... #Hyperthermia #comparison
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Management Summary Causes ... Muscle swelling - Fever ... Treatment of underlying ... Diagnosis #Management #causes ... #treatment #nephrology